Note: Kentucky Wesleyan was a charter member of the Mid-South Football Conference from 1987-89. The Panthers rejoined the Mid-South Conference for football only in 2004 and 2005. KWC joined the Great Lakes Football Conference in 2006 as a charter member. The Panthers joined the Great Lakes Valley Conference in 2012 as a charter member and the Great Midwest Athletic Conference in 2015.

Year	Overall W-L (pct.)	Mid-South Conference W-L (place)	Head Coach
1983	3-5 (.375)		Billy Mitchell
1984	3-6-1 (.350)		Billy Mitchell
1985	2-6-2 (.222)		Billy Mitchell
1986	4-6 (.400)		Billy Mitchell
1987	3-6 (.333)	0-4 (5th)	Billy Mitchell
1988	4-6 (.400)	1-4 (4th)	Billy Mitchell
1989	3-6-1 (.350)	1-4-1 (6th)	Billy Mitchell (22-41-3, 7 years)
1990	0-10 (.000)		Randy Awrey
1991	2-8 (.200)		Randy Awrey
1992	3-7 (.300)		Randy Awrey
1993	6-4 (.600)		Randy Awrey (11-29, 4 years)
1994	5-5 (.500)		John Johnson
1995	5-5 (.500)		John Johnson
1996	3-8 (.273)		John Johnson
1997	6-4 (.600)		John Johnson
1998	2-7 (.222)		John Johnson
1999	7-4 (.636)		John Johnson
2000	4-6 (.400)		John Johnson
2001	1-9 (.100)		John Johnson
2002	1-10 (.090)		John Johnson (34-58, 9 years)
2003	1-9 (.100)		Brent Holsclaw
		Mid-South Conference W-L (place)
2004	4-7 (.364)	4-6 (6th)	Brent Holsclaw
2005	3-7 (.300)	3-5 (T-4th West)	Brent Holsclaw
		Great Lakes Football Conference W-L (place)
2006	0-11 (.000)	0-5 (6th)	Brent Holsclaw
2007	3-8 (.273)	1-4 (4th)	Brent Holsclaw
2008	4-6 (.400)	2-1 (5th)	Brent Holsclaw
2009	2-9 (.182)	2-2 (3rd)	Brent Holsclaw
2010	5-6 (.400)	0-3 (4th)	Brent Holsclaw
2011	1-10 (.091)		Brent Holsclaw
		Great Lakes Valley Conference W-L (place)
2012	2-9 (.182)	0-8 (9th)	Brent Holsclaw
2013	0-11 (.000)	0-7 (8th)	Brent Holsclaw
2014	7-4 (.636)		Brent Holsclaw
		Great Midwest Athletic Conference W-L (place)
2015	4-6 (.400)		Brent Holsclaw
2016	3-8 (.273)	1-1	Brent Holsclaw
2017	2-8 (.200)	1-6 (8th)	Brent Holsclaw (41-119, 15 years)
2018	3-7 (.300)	2-6 (7th)	Interim HC Taurean Smith (3-7, 1 year)
2019	1-10 (.091)	1-6 (8th)	Craig Yeast

2020

1-4 (.200)

1-4 (5th)

Craig Yeast (2-14, 2 years)